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Really interesting and thought provoking, especially the neuromelanin angle. Dopamine is actually created and used in the eyes - in the retina. Dr Greg Willis injected tiny amounts of l-dopa into the eyes of parkinson's mice, and showed this was effective at relieving the symptoms as giving much larger doses orally. Willis's theory is that it is not that dopamine is low. but that that the ying-yang of the dopamine-melatonin becomes unbalanced, and melatonin becomes too high as a result. His stratergy was to attack melatonin at its peak.

From a paper by willis "In the early years of dopamine theory it was generally accepted that the more severe the cell loss, the more severe the dopamine deficiency and the more severe the Parkinson’s disease. However, this position has been very gradually eroded by the ongoing demonstration that this relationship is a poor one. In fact, recent work has demonstrated that Parkinson’s disease can develop with only 30% loss of dopamine (Annals of Neurology, 67(6) 715-725, 2010) suggesting that it is not only the level of dopamine that is important. This has important implications for treating the disease and is consistent with our approach using coordinated drug and light treatment."

""[From] our experience with the application of bright light therapy, we have identified numerous technical problems in the therapeutic application of light that frequently interferes with efficacy and which have to be overcome before the patient can experience optimal therapeutic benefit. Such technical problems include positioning of the light source, compliance, pre-existing ocular disease, light sensitivity, consistency in time of administration, polypharmacy, DA replacement overdosing, sleep hygiene and light induced narcolepsy, to name only a few. Such problems are typically resolved in routine neurological practice over the first few visits to the clinic."

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May 6Liked by Roman S Shapoval

Wow! I need to re-read your wonderful article.

Light, albeit contaminated with chemtrails, is fascinating.

And do not forget Stephanie Seneff and Anthony Samsel's glyphosate contribution.

Here is a case report.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663540/

Parkinsonism Relating to Intoxication with Glyphosate

"Our patient had a low density of dopamine transporters in the striatum, which suggested a loss of dopaminergic neurons similar to that found in sporadic PD."

Thank you!

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Sally (and Roman), I was just about to weigh in on this and mention glyphosate. I don't doubt that natural light vs. artificial could be a huge contributing factor. I'm just thinking about my friend's Mennonite farmer friend down the road who has Parkinson's. No cell phones in the home, no electricity either. And, being a farmer, I imagine he's been up before dawn most of his life. And sadly, also using pesticides...

That being said, I'm a huge believer in getting out in that early morning light before I even think about turning my phone on. Thx for another comprehensive article, Roman!

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May 6·edited May 6Author

Dear Sally and Barbara, thank you so much for your comments - they've inspired a potential future article. There is so much to unravel with PD, and glyphosate also has a light connection, as it replaces glycine, a major protein / building block for our body. As it turns out, glycine does not bind to metal atoms such as iron, thus allowing sunlight to remain in our cells, and have that light polarized (filtered) in a specific way that cells use for signaling. (Jack Kruse)

Glyphosate ruins cell signaling for the same reason. Glyphosate residue also causes the colllagen in those cells not to transfer energy to our exclusion zone (structured, 4th phase of water where cellular stress is buffered) and we lose our ability to remain piezoelectric. Electricity is the basis of our metabolism, and when impaired by chemicals, we lose our "spark." Hope this makes sense? This is my understanding.

Study " Glyphosate works synergistically with other factors, such as insufficient sun exposure" https://www.mdpi.com/1099-4300/15/4/1416

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Thx, Roman! "Hope this makes sense?" That made me laugh out loud. :) You know me and science...

My simplistic conclusion would be Sun/good, glyphosate/bad! Glad we inspired a potential article. Have a beautiful day! I'm off into the woods... 🌲🌲🌲

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Enjoy Barbara! Thanks so much for taking the time to stop by and chime in.

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May 6Liked by Roman S Shapoval

What about totally blind people? Those born with underdeveloped optic nerves. They get no light into their eyes. Do they have higher rates of Parkinson’s?

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I once asked this of a PD community, but it wasn't clear whether being blind was protective. Eye detoriation is a very common feature of PD though.

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Does wearing contact lenses affect light taken in by the eyes?

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Great question Lori. It depends, but most lenses block UV, and some even infrared:

https://pubmed.ncbi.nlm.nih.gov/7731651/

https://pubmed.ncbi.nlm.nih.gov/20120574/

Can you see the Sunrise with no lenses?

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The contacts I wear currently do have a blue tint, different from the past version I wore which are no longer available. I can see the difference in light when using blue blockers or warm screens. I do try to reduce blue at night and get as much natural light during the day as possible.

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May 6Liked by Roman S Shapoval

Your article is of interest to me bc several years ago I started seeing a neurologist to receive a diagnosis and treatment for my tremors in my left arm and leg. The doctor said he was 95% sure it was PD or would develop into PD. Since then, of course, I have been paying attention to ways I can repair the damage or at least stop its progression. This is the first time I have heard of light as a source of help or hurt. As I sit here reading your article in the morning on my phone, … I’m quite convicted. Also I am quite a sunglasses wearer since I had LASEK almost two decades ago. I do love sunrises and sunsets, and I don’t need sunglasses for either of those. Bone broth is already in my daily intake tho not at every meal. I wonder about genetics in the development of PD. My maternal grandmother had PD. Living intentionally closer to the earth is hard. Thank you for your article.

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Hi Katrina, thanks so much for your thoughtful comment. I'm linking to some articles I've written - hope you're not overwhelmed:

Lasik can be an issue as surgery of the lens/cornea destroys neuropsin and melanopsin in the eye and frees Vitamin A, which can then create havoc:

https://romanshapoval.substack.com/i/111244879/vitamin-a-dont-be-a-carrot-be-the-light

I also didn't go into how radiofrequency radiation from wireless induces hypoxia (lack of oxygen) along with magnetizing the iron in melanin and our brain to cause disorientation, and potentially effect cognition:

https://romanshapoval.substack.com/p/acmagnetic

The genetic factor could also be epigenetic, and sometimes PD can also have roots in emotional trauma (a family member of mine refuses to let go of past hurt, and has always been rigid, this state of mind is now playing out in their body).

Tremors can also be caused by Wi-Fi, as radiation can disrupt how acetylcholine (neurotransmitter for motor movement,heart, brain) fires.

Great to know that you're sipping on bone broth! Avoid glyphosate as much as possible too, as it disrupts glycine production/ sunlight absorption.

Hope this helps. Do you sleep well?

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May 6Liked by Roman S Shapoval

Wow that is a lot to take in! I do try to eat organic to avoid glyphosate. Most nights I do sleep well. I supplement with glycine and usually some ignatia before bedtime, which seems to help me sleep well.

Since I started reading Substack for health improvement, it has become rather overwhelming to sort through and prioritize all the changes I am learning that I need to make. Some of it is quite costly too. Nevertheless, I do appreciate the thoughtful information.

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I hear you Katrina, little changes are huge - why I make sure that if nothing else for that day, I see the Sunrise, as its quantum effects are enormous. Thanks again for sharing a little bit about yourself - sounds like you're doing what you can to prioritize your health, so I congratulate you on that front!

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May 6Liked by Roman S Shapoval

Thank you. The more humanity realizes how important our environment is in reference to our gene expression the better. Too many are living in fear due to genetics and illnesses in the family when in reality our current and future state of wellness is largely in our hands.

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May 6Liked by Roman S Shapoval

Does any of this relate to cataracts also?

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Great queston Jody. Cataracts are caused by the build up / misfolding of crystallin proteins in the eye, however it's interesting to note that studies have shown that increased vit D levels lead to a reduction in cataracts: https://pubmed.ncbi.nlm.nih.gov/26132781/

We make vitamin D by absorbing UV-B in the presence of LDL cholesterol. So why would something that's supposed to cause cataracts and be bad for us (UV) actually help them?

Or could it be the unbalanced blue light environment we're all exposed to? hmm....(:

Does this help answer your question? Are you sensitive to sunlight at any time of day? Can you see the Sunrise?

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May 9Liked by Roman S Shapoval

When screen-staring, recommendation i think coming from Russian Academy researchers re e-smog, one should be sure to not have that as the exclusive light source. Well before I learned of this recommendation, I found that symptoms from screen use were lessened by having sunlight coming at my eyes at the same time. After one period of intense computer screen use around 2010 I began suffering from actual pain in one eye (eventually in both). As now when I get early warning tearing or discomfort, I resort to covering the suffering eye and/or the general area upper head with just minimum aperture for reading, with silver-lined cotton cloth. Better still has been resort to a projector instead, even if light source is still LED, reflected from non-smooth surface the singularity of polarization is lessened. This polarization factor is not often considered and may be decisive, not necessarily or as much offending wavelength. When involved in advocacy against e-smog, i used to refer to a NASA graphic re atmospheric opacity - that some wavelengths are effectively blocked must be for out benefit, but that others are not should give one pause that people should not be exploiting this range surely needed for biological flourishing. If a wavelength is not blocked but is still found to be harmful, the polarization factor may be at the crux and thus may be remediable to an extent. One researcher suggested some 15 yr ago, based on findings that relatively continuous waves did not induce as much bio-harm as waves with pulsed patterning for info-carrying (even continuous is not really so if eg grid-borne, eg a MW oven will pulse at least at 60 hz, too); he suggested insertion of "noise" to break up the regular periodicity suspected of causing its harm. Breaking up the artificial and xenobiotic patterns may be most crucial.

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Dyr, wow, thank you so much for all this info. Makes sense as polarization = filtering. I never thought to use a silver cloth, and agree that the dirty electricity in our home can effectively pulse lights and appliances, if this is what you're referring to? FYI we'll be releasing a podcast tomorrow morning that we recorded with an expert in blue light LEDs, who is suing the US government for harm.

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I think the earlier research on pulsed vs continuous wave was in particular by Litowitz (on chickens, Notre Dame), and Goldsworthy (Imperial College, London, persecuted as others for his cluing in to and speaking out about e-smog, despite being a radio adept himself) was the fellow who was suggesting the "noise" to possibly break up some toxic effect. That graphic i referred to can be seen eg at https://commons.wikimedia.org/wiki/File:Atmospheric_electromagnetic_opacity.svg .

At a conference held at Women's College Hospital the author of the useless study on microwave and e-harm generally, requested by the Ontario govt which was disturbed by our and others' advocacy at the time esp. re then recent wifi in long term care facilities and others' re wifi in schools, Copes as invitee spoke and made of use of the obfuscatory graphic that makes no reference at all to the differentiation throughout the spectrum (and went silent when challenged on this), much as industry-connected hacks testing for human safety make no or next to no distinctions re incident power effects on our bodies, moreover taking as primary study subject big men or mere saline solution mock-ups. See also Maisch's The Procrustean Approach. Leitgeb found, per what Martin Blank told me, up to 100x difference in skin level conductivity among people. But what is especially ignored through all this in the mainstream and much dissidence, is the role of low resistance energy meridians, central eg esp in acupuncture, and during covidiana with my apparently unusual ability to detect who is and isn't a carrier of vax toxicities, the symptomatic effects have been right on or by these meridians typically. I.e. as reported from early on in covi-dissidence but not in this way re effect of being near injectees, "carriers" incl those uninjected "secondaries" who have spent too much time around primary vaxee carriers thus likely at least having breathed in some toxic load; carriers put out toxic frequencies, or with toxic patterns. I get clots which when coming loose are felt as throbs. Mostly our big antenna, gall bladder meridian, is involved, but various others as well, commonly large intestine or urinary bladder. I don't know if through the eyes as you refer to would relate to liver or gall bladder meridians especially as I would think. Or if the pain I feel relates to retinal harm, a warning feeling as i do not think the retina considered as brain part feels pain, but as I experience improvement (esp re herbal treatment) re Li/GB function I need the eye/head protection less or not at all. Also when using the cotton with silver cloth be careful as these do deteriorate after lots of use and I think the silver gets more exposed and transfers directly to skin what is unwanted. This also occurs when the thing gets wet - eg I have had to wear it when doing work for an extended time stationary near our neighbour's who no longer at our request turns off his emitters. My symptom would be verbal, cognitive, jumbling, but i can spend longer without symptoms with the head covering, but if it is raining or I sweat too much and it is absorbed (usually the time spent 'd be wood-splitting etc) the e-transference must be occurring as I feel the skin irritation. Re polarization, Greek researcher Panagopoulos (also persecuted) has written about this, and with him i shared the following from a book but whose author did not reply to my further inquiry:

............

From: ck872@sympatico.ca

To:

Sent: Tuesday, May 14, 2013 5:56 AM

Subject: polarization

On the last page of Werner Loewenstein's new Physics in Mind: A

Quantum View of the Brain, when I came across the name of his one-time

close colleague, Herbert Frohlich, in whose edited book, Biological

Coherence and Response to External Stimuli ('88), I saw what promising

research avenues got thwarted that could have led to saving us from

mass emf assault sooner; and then reading WL's last lines, made me

think of what you have intimated about the role of polarization in

describing manmade emf harm:

" [...] a helpful hint regarding macromolecules. It concerns the

general noise problem with large molecules in thermal equilibrium, the

cruel paradox of seeing one's readout signals fade with the increasing

number of nuclear spins in a molecule [...]. As it turns out, the

problem can be overcome by polarization. This solution hadn't been

known [when e.g. he and HF worked on a "search for quantum waves in

cell junctions, the tightly adhering spots of cell membranes", in the

'60s]. Quantum computer engineers had overlooked the polarization

factor -- but it's unlikely Lady Evolution had."

[...]

Daryl

.............

Roman, you are doing good work and perhaps there is much more to share further between us suggestive for you of further ways to help others get what is going on and how to mitigate. The email address above is defunct - Bell killed its dial up we used for a decade here so we had to go to the only alternative - but the 5 characters to the left of the @ can be used @xplore.net to reach us.

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May 7Liked by Roman S Shapoval

Thank you for another fascinating and actionable post! I'm even going to share it!

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Hi Lisa, thanks so much for your support!!! I'm fascinated with the power of light, as you can tell (: Our eyes are truly more powerful than we know ha.

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